Journal Article

Oestrogenicity of orthodontic adhesive resins

T Eliades, V Gioni, D Kletsas, AE Athanasiou and G Eliades

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 29, issue 4, pages 404-407
Published in print August 2007 | ISSN: 0141-5387
Published online August 2007 | e-ISSN: 1460-2210 | DOI:
Oestrogenicity of orthodontic adhesive resins

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The purpose of this study was to assess the oestrogenic action of a chemically cured, no-mix (Rely-a-Bond) and a light-cured (Reliance) orthodontic adhesive resin. The adhesives were bonded to 40 stainless steel maxillary incisor brackets (Diamond) divided into two equal groups, employing a method which simulated the clinical handling of materials. In total, three series of specimens were prepared for each adhesive–bracket group. All specimens were immersed in normal saline. Samples of eluent were removed from each group at 1 day and 1 week following incubation and tested for oestrogenicity by measuring their effect on the proliferation of the oestrogen-responsive MCF-7 breast cancer cells, while an oestrogen-insensitive cell line (MB-231 human breast adenocarcinoma) was used as a control.

Three-way analysis of variance with adhesive, concentration of eluent, and immersion period were used as discriminating variables. No evidence was found of stimulation of proliferation of these cells, indicating the absence of any oestrogenicity of orthodontic adhesive eluents.

Journal Article.  2673 words.  Illustrated.

Subjects: Restorative Dentistry and Orthodontics

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