Journal Article

Expression of Sox 9 and type II and X collagens in regenerated condyle

Tadashi Fujita, Mao Nakano, Junji Ohtani, Toshitsugu Kawata, Masato Kaku, Masahide Motokawa, Natsumi Tsuka, Hidetaka Hayashi and Kazuo Tanne

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 32, issue 6, pages 677-680
Published in print December 2010 | ISSN: 0141-5387
Published online April 2010 | e-ISSN: 1460-2210 | DOI: http://dx.doi.org/10.1093/ejo/cjp163
Expression of Sox 9 and type II and X collagens in regenerated condyle

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The present study was designed to examine the expression of Sox 9 and type II and X collagens in regenerated condyle resulting from the use of a functional appliance. Ninety, 3-week-old, mice were divided equally into the following groups: two experimental groups (condylectomy group and condylectomy with functional appliance group) and the corresponding control group. In the condylectomy group, a unilateral condylectomy was performed on the right side. In the condylectomy with appliance group, the mandible was repositioned in a forward direction using a functional appliance after unilateral condylectomy. The expression of Sox 9 and type II and X collagens in the condyle was determined immunohistochemically 4 weeks after surgery.

In mice with a condylectomy, the expression was minimal. On the other hand, these factors were highly expressed in the condylectomized side with the appliance. It is thus speculated that cartilaginous regeneration is due to the expression of chondrogenic factors, such as Sox 9 and type II and X collagens. It is also suggested that condyle regeneration results from an optimal intra-articular environment with appropriate joint spaces achieved by condylar repositioning.

Journal Article.  2297 words.  Illustrated.

Subjects: Restorative Dentistry and Orthodontics

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