Journal Article

Bone changes in the mandible following botulinum neurotoxin injections

Chi-Yang Tsai, Yi-Ming Shyr, Wan-Chi Chiu and Chi-Ming Lee

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 33, issue 2, pages 132-138
Published in print April 2011 | ISSN: 0141-5387
Published online September 2010 | e-ISSN: 1460-2210 | DOI: http://dx.doi.org/10.1093/ejo/cjq029
Bone changes in the mandible following botulinum neurotoxin injections

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In this study, botulinum neurotoxin type A (BoTx/A) was injected into the temporalis and masseter muscles of growing rats to induce masticatory hypoactivity.

Sixty, 30-day-old, male Long-Evans rats were randomly divided into four groups. BoTx/A was bilaterally injected in the masseter muscles in group I, in the temporalis muscles in group II, and into both the masseter and the temporalis muscles in group III. Group IV served as the control in which saline was bilaterally injected into both muscles. Forty-five days after the injections, the rats were sacrificed. Observation of cortical bone thickness from bone biopsies of the right halves of the mandibles, evaluation of the volume of masseter and temporalis muscles with a plethysmometer, and scanning of bone mineral density (BMD) of the skull and mandibular bone structure with dual-energy X-ray absorptiometry were performed. One-way analysis of variance was employed to analyse measurements of muscle volume, BMD, and cortical bone thickness among the groups. The least square difference was then used to determine significance.

Reduced cortical bone thickness and BMD of the skull and mandibular bone structure were observed. The volumes of the temporalis and masseter muscles injected with BoTx/A were smaller. Masticatory hypofunction affects bone structure during development.

Journal Article.  4051 words.  Illustrated.

Subjects: Restorative Dentistry and Orthodontics

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