Journal Article

Turner syndrome isochromosome karyotype correlates with decreased dental crown width

S. Rizell, M.-L. Barrenäs, A. Andlin-Sobocki, C. Stecksén-Blicks and H. Kjellberg

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 34, issue 2, pages 213-218
Published in print April 2012 | ISSN: 0141-5387
Published online February 2011 | e-ISSN: 1460-2210 | DOI: http://dx.doi.org/10.1093/ejo/cjq196
Turner syndrome isochromosome karyotype correlates with decreased dental crown width

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The aim of this project was to study possible influences of Turner syndrome (TS) karyotype and the number of X chromosomes with intact short arm (p-arm) on dental crown width. Primary and permanent mesio-distal crown width was measured on plaster casts from 112 TS females. The influence on crown width of four karyotypes: 1. monosomy (45,X), 2. mosaic (45,X/46,XX), 3. isochromosome, and 4. other, and the number of intact X chromosomal p-arms were investigated. In comparisons between karyotypes, statistically significant differences were found for isochromosome karyotype maxillary second premolars, canines, laterals, mandibular first premolars, and canines, indicating that this karyotype was the most divergent as shown by the most reduced crown width. When each karyotype group were compared versus controls, all teeth in the isochromosome group were significantly smaller than controls (P < 0.01–0.001). The 45,X/46,XX karyotype expressed fewer and smaller differences from controls, while 45,X individuals seemed to display an intermediate tooth width compared with 45,X/46,XX and isochromosomes. No significant difference in crown width was found comparing the groups with one or two intact X chromosomal p-arms. Both primary and permanent teeth proved to have a significantly smaller crown width in the entire group of TS females compared to healthy females. We conclude that the isochromosome group deviates most from other karyotypes and controls, exhibiting the smallest dental crown width, while individuals with 45,X/46,XX mosaicism seemed to have a less affected crown width. An influence of the number of intact p-arms on crown width could not be demonstrated in this study.

Journal Article.  3765 words. 

Subjects: Restorative Dentistry and Orthodontics

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