Journal Article

Assessment of serum dehydroepiandrosterone sulphate in subjects during the pre-pubertal, pubertal, and adult stages of skeletal maturation

Bhadrinath Srinivasan and Sridhar Premkumar

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 34, issue 4, pages 447-451
Published in print August 2012 | ISSN: 0141-5387
Published online April 2011 | e-ISSN: 1460-2210 | DOI: http://dx.doi.org/10.1093/ejo/cjr041
Assessment of serum dehydroepiandrosterone sulphate in subjects during the pre-pubertal, pubertal, and adult stages of skeletal maturation

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The aim of this cross-sectional study was to evaluate serum levels of the hormone, dehydroepiandrosterone sulphate (DHEAS), during the pre-pubertal, pubertal, and adult stages of skeletal maturation based on the methods of Björk and Grave and Brown of assessing hand–wrist radiographs. The levels of the DHEAS of each individual were measured using quantitative enzyme-linked immunosorbent assay and correlated with the corresponding stages in their hand–wrist radiograph. This study was performed on 60 subjects (30 females and 30 males) aged from 7 to 30 years.

Analysis of variance followed by a Tukey honestly significant difference test showed that the serum levels of the DHEAS were statistically significant at (P < 0.01) in all three groups. The serum levels were significant (P < 0.05) when each of the three groups were individually compared with the other two groups. The mean DHEAS levels were 0.43 ± 0.28, 2.17 ± 0.92, and 4.60 ± 1.34 μg/ml in the pre-pubertal, pubertal, and adult groups, respectively. There was a gradual increase in the hormonal level with progressing skeletal age. The adult group showed the highest DHEAS level and the pre-pubertal group the lowest.

Serum levels of DHEAS showed a constant increase from pre-puberty to adulthood, and at the same level of skeletal maturation, both females and males had similar hormone levels. This finding highlights the fact that the hormone DHEAS plays a significant role and can be a valuable tool in assessing skeletal maturation.

Journal Article.  2927 words.  Illustrated.

Subjects: Restorative Dentistry and Orthodontics

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