Journal Article

Wnt signaling in the murine diastema

Thantrira Porntaveetus, Atsushi Ohazama, Hong Y. Choi, Joachim Herz and Paul T. Sharpe

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 34, issue 4, pages 518-524
Published in print August 2012 | ISSN: 0141-5387
Published online April 2011 | e-ISSN: 1460-2210 | DOI: http://dx.doi.org/10.1093/ejo/cjr049
Wnt signaling in the murine diastema

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The correct number and shape of teeth are critical factors for an aesthetic and functional dentition. Understanding the molecular mechanisms regulating tooth number and shape are therefore important in orthodontics. Mice have only one incisor and three molars in each jaw quadrant that are divided by a tooth-less region, the diastema. Although mice lost teeth in the diastema during evolution, the remnants of the evolutionary lost teeth are observed as transient epithelial buds in the wild-type diastema during early stages of development. Shh and Fgf signaling pathways that are essential for tooth development have been shown to be repressed in the diastema. It remains unclear however how Wnt signaling, that is also required for tooth development, is regulated in the diastema. In this study we found that in the embryonic diastema, Wnt5a expression was observed in mesenchyme, whereas Wnt4 and Wnt10b were expressed in epithelium. The expression of Wnt6 and Wnt11 was found in both tissues. The Wnt co-receptor, Lrp6, was weakly expressed in the diastema overlapping with weak Lrp4 expression, a co-receptor that inhibits Wnt signaling. Secreted Wnt inihibitors Dkk1, Dkk2, and Dkk3 were also expressed in the diastema. Lrp4 mutant mice develop supernumerary teeth in the diastema that is accompanied by upregulation of Wnt signaling and Lrp6 expression. Wnt signaling is thus usually attenuated in the diastema by these secreted and membrane bound Wnt inhibitors.

Journal Article.  3444 words.  Illustrated.

Subjects: Restorative Dentistry and Orthodontics

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