Journal Article

Why does clustering matter in orthodontic trials?

Jayne E. Harrison and Girvan Burnside

in The European Journal of Orthodontics

Published on behalf of European Orthodontics Society

Volume 34, issue 3, pages 293-295
Published in print June 2012 | ISSN: 0141-5387
Published online June 2012 | e-ISSN: 1460-2210 | DOI: http://dx.doi.org/10.1093/ejo/cjs026
Why does clustering matter in orthodontic trials?

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Clustering in RCTs occurs when participants or units are allocated to an intervention in a group rather than independently or when multiple measurements are taken from the same individual. Cluster RCTs occur frequently in clinical orthodontic research; however, only a quarter of published trials take account of the effects of clustering in the design and analysis of these trials. The effects of clustering needs to be considered when calculating the sample size required to detect a difference in treatment effect, obtaining consent for participation in the trial and finally the analysis of the data.

Journal Article.  1807 words. 

Subjects: Restorative Dentistry and Orthodontics

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