Journal Article

Vitamin B<sub>12</sub> Intake and Status and Cognitive Function in Elderly People

Esmée L. Doets, Janneke P. van Wijngaarden, Anna Szczecińska, Carla Dullemeijer, Olga W. Souverein, Rosalie A. M. Dhonukshe-Rutten, Adrienne E. J. M. Cavelaars, Pieter van 't Veer, Anna Brzozowska and Lisette C. P. G. M. de Groot

in Epidemiologic Reviews

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 35, issue 1, pages 2-21
Published in print January 2013 | ISSN: 0193-936X
Published online December 2012 | e-ISSN: 1478-6729 | DOI:
Vitamin B12 Intake and Status and Cognitive Function in Elderly People

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Current recommendations on vitamin B12 intake vary from 1.4 to 3.0 μg per day and are based on the amount needed for maintenance of hematologic status or on the amount needed to compensate obligatory losses. This systematic review evaluates whether the relation between vitamin B12 intake and cognitive function should be considered for underpinning vitamin B12 recommendations in the future. The authors summarized dose-response evidence from randomized controlled trials and prospective cohort studies on the relation of vitamin B12 intake and status with cognitive function in adults and elderly people. Two randomized controlled trials and 6 cohort studies showed no association or inconsistent associations between vitamin B12 intake and cognitive function. Random-effects meta-analysis showed that serum/plasma vitamin B12 (50 pmol/L) was not associated with risk of dementia (4 cohort studies), global cognition z scores (4 cohort studies), or memory z scores (4 cohort studies). Although dose-response evidence on sensitive markers of vitamin B12 status (methylmalonic acid and holotranscobalamin) was scarce, 4 of 5 cohort studies reported significant associations with risk of dementia, Alzheimer's disease, or global cognition. Current evidence on the relation between vitamin B12 intake or status and cognitive function is not sufficient for consideration in the development of vitamin B12 recommendations. Further studies should consider the selection of sensitive markers of vitamin B12 status.

Keywords: aged; cognition; dementia; nutritional requirements; recommended dietary allowances; review; vitamin B12

Journal Article.  9661 words.  Illustrated.

Subjects: Public Health and Epidemiology

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