Journal Article

The Epidemiology of Longevity and Exceptional Survival

Anne B. Newman and Joanne M. Murabito

in Epidemiologic Reviews

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 35, issue 1, pages 181-197
Published in print January 2013 | ISSN: 0193-936X
Published online January 2013 | e-ISSN: 1478-6729 | DOI: http://dx.doi.org/10.1093/epirev/mxs013
The Epidemiology of Longevity and Exceptional Survival

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The field of the “epidemiology of longevity” has been expanding rapidly in recent years. Several long-term cohort studies have followed older adults long enough to identify the most long-lived and to define many factors that lead to a long life span. Very long-lived people such as centenarians have been examined using case-control study designs. Both cohort and case-control studies have been the subject of genome-wide association studies that have identified genetic variants associated with longevity. With growing recognition of the importance of rare variations, family studies of longevity will be useful. Most recently, exome and whole-genome sequencing, gene expression, and epigenetic studies have been undertaken to better define functional variation and regulation of the genome. In this review, we consider how these studies are leading to a deeper understanding of the underlying biologic pathways to longevity.

Keywords: aging; exome; genetics; genome; longevity

Journal Article.  9948 words.  Illustrated.

Subjects: Public Health and Epidemiology

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