Journal Article

Cardiac resynchronization therapy for adult congenital heart disease patients with a systemic right ventricle: analysis of feasibility and review of early experience

Gerhard-Paul Diller, Darlington Okonko, Anselm Uebing, Siew Yen Ho and Michael A. Gatzoulis

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 8, issue 4, pages 267-272
Published in print April 2006 | ISSN: 1099-5129
Published online January 2006 | e-ISSN: 1532-2092 | DOI: http://dx.doi.org/10.1093/europace/euj048
Cardiac resynchronization therapy for adult congenital heart disease patients with a systemic right ventricle: analysis of feasibility and review of early experience

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Aims Patients with a systemic right ventricle (RV) frequently develop heart failure and may benefit from cardiac resynchronization therapy (CRT). We aimed to assess the proportion of unselected patients with a systemic RV eligible for CRT and to review available data on the effect of CRT in congenital heart disease patients.

Methods and results Adhering to criteria derived from landmark CRT trials, we determined the eligibility of patients with a systemic RV for CRT. Seventy-five transposition of the great arteries (TGA) patients (age 29.5±10.2 years) and 49 patients with congenitally corrected (cc) TGA (age 36.2±12.8 years) were studied. Full criteria for CRT were met in 4.0% of the TGA patients and 4.1% of the ccTGA patients. Including New York Heart Association class 2 patients, 9.3% of TGA and 6.1% of ccTGA patients were eligible for CRT.

Conclusion Four to 9% of unselected patients with a systemic RV appear to be potential candidates for CRT. Although large clinical studies are currently lacking, available data consistently demonstrate that CRT improves haemodynamics in congenital heart disease patients and warrants further investigation.

Keywords: Congenital heart disease; Systemic right ventricle; Cardiac resynchronization therapy

Journal Article.  3436 words. 

Subjects: Cardiovascular Medicine

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