Journal Article

Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing

Houman Ashrafian, Mark J. Mason and Andrew G. Mitchell

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 9, issue 1, pages 50-54
Published in print January 2007 | ISSN: 1099-5129
Published online January 2007 | e-ISSN: 1532-2092 | DOI: http://dx.doi.org/10.1093/europace/eul137
Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing

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The evolution of hypertrophic cardiomyopathy (HCM) towards dilatation and hypokinesis is an increasingly recognized complication with a high incidence of adverse outcomes, including sudden cardiac death, requiring defibrillator implantation and cardiac transplantation. It is generally regarded as the irreversible ‘burnt-out’ end-stage manifestation of HCM. We report one of the first cases of profound regression of the dilated-hypokinetic state by the application of biventricular pacing and cardiac resynchronization therapy (CRT). Reviewing the literature on the role of pacing in HCM and the energetic rationale for CRT in HCM prompts us to suggest that further systematic studies are needed urgently to assess the role of CRT in HCM variants.

Keywords: Dilated-hypokinetic; Hypertrophic cardiomyopathy; Cardiac resynchronization therapy; Biventricular pacing

Journal Article.  1825 words.  Illustrated.

Subjects: Cardiovascular Medicine

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