Journal Article

Syncope in hypertrophic cardiomyopathy: mechanisms and consequences for treatment

Lynne Williams and Michael Frenneaux

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 9, issue 9, pages 817-822
Published in print September 2007 | ISSN: 1099-5129
Published online May 2007 | e-ISSN: 1532-2092 | DOI:
Syncope in hypertrophic cardiomyopathy: mechanisms and consequences for treatment

Show Summary Details


Hypertrophic cardiomyopathy (HCM) is an inherited disease with marked phenotypic variability that includes the extent of hypertrophy, the presence and severity of symptoms, and the natural history of the disease. Symptoms of impaired consciousness (syncope and pre-syncope) occur in approximately 15–25% of patients with hypertrophic cardiomyopathy (HCM). In young patients a history of recurrent syncope is associated with an increased risk of sudden death. Detailed investigations identify a probable mechanism in a minority of these, usually paroxysmal atrial fibrillation or ventricular tachycardia. In the majority, however, no likely mechanism is found despite extensive investigation. Although this may be the case, it is still of vital importance to exclude potentially treatable causes of syncope.

Keywords: Hypertrophic cardiomyopathy; Syncope; Sudden death; Arrhythmias; Abnormal vascular control

Journal Article.  4599 words. 

Subjects: Cardiovascular Medicine

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