Journal Article

Clinical predictors of atrial fibrillation in Brugada syndrome

Mohamad Ali Babai Bigi, Amir Aslani and Shahab Shahrzad

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 9, issue 10, pages 947-950
Published in print October 2007 | ISSN: 1099-5129
Published online May 2007 | e-ISSN: 1532-2092 | DOI: http://dx.doi.org/10.1093/europace/eum110
Clinical predictors of atrial fibrillation in Brugada syndrome

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Aims Atrial arrhythmias have been reported in patients with Brugada syndrome. The aim of this study was to evaluate clinical predictors of atrial fibrillation (AF) in Brugada syndrome.

Methods and results Patients diagnosed with Brugada ECG pattern were enrolled in the study. Type 1, 2, and 3 Brugada ECG pattern was found in 28, 56, and 31 patients, respectively. A total of 85 healthy age and gender-matched subjects were selected as a control group. Mean age, maximum P-wave duration (Pmax), P-wave dispersion (Pdisp), and left atrial dimension were not significantly different between patients and controls. There were no differences between Pmax, Pdisp, and left atrial dimension of the type 1, 2, and 3 Brugada patients. Spontaneous paroxysmal AF was detected in 15 of 28 type 1 Brugada patients (53%) and none of the type 2 and 3 Brugada patients. All 15 patients with AF had at least one episode of paroxysmal AF and none of the patients showed persistent or chronic AF. All 15 patients who had paroxysmal AF had previous life threatening cardiac events. In contrast, paroxysmal AF did not occur in type 1 Brugada patients without previous life threatening cardiac events. In multiple regression analysis, only the occurrence of previous life threatening cardiac events was a risk factor for paroxysmal AF (P = 0.0001).

Conclusion It is concluded that the most important predictor of AF in Brugada syndrome is the occurrence of previous life threatening cardiac events.

Keywords: Atrial fibrillation; Brugada syndrome; Ventricular fibrillation

Journal Article.  2375 words. 

Subjects: Cardiovascular Medicine

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