Journal Article

Gender-related differences in catheter ablation of atrial fibrillation

Giovanni B. Forleo, Claudio Tondo, Lucia De Luca, Antonio Dello Russo, Michela Casella, Valerio De Sanctis, Fabrizio Clementi, Rafael Lopes Fagundes, Roberto Leo, Francesco Romeo and Massimo Mantica

in EP Europace

Published on behalf of European Heart Rhythm Association of the European Society of Cardiology (ESC)

Volume 9, issue 8, pages 613-620
Published in print August 2007 | ISSN: 1099-5129
Published online July 2007 | e-ISSN: 1532-2092 | DOI: http://dx.doi.org/10.1093/europace/eum144
Gender-related differences in catheter ablation of atrial fibrillation

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Aims Women have an increased risk for atrial fibrillation (AF)-related complications and there is evidence towards a reduced efficacy of the rhythm control strategy than men. A catheter-based strategy is therefore widely attractive, but the impact of gender on catheter ablation (CA) of AF remains undefined.

Methods and results We included 221 consecutive patients (150 men) who underwent CA of drug-refractory AF. Gender differences in clinical presentation and outcomes were compared. Women were older (P = 0.002), had a longer history of AF (P = 0.04), and were more likely to have hypertension (P = 0.04). Moreover, a concomitant valvular heart disease tended to be more common in women (32.4 vs. 23.3%; P = 0.28) and left atrium dimensions were significantly larger (P = 0.003). However, acute success rate and complications rate were similar between genders. After 22.5 ± 11.8 months of follow-up, the overall freedom from arrhythmia recurrences was similar (83.1 vs. 82.7% in men), and a similar improvement in SF-36 quality of life scores was achieved in both groups.

Conclusion Women are referred for AF ablation later with a more complex clinical pre-operative presentation. Despite this higher risk profile in women, no differences were detected in clinical outcomes. Our findings indicate that CA of AF appears to be safe and effective in women as in men.

Keywords: Atrial fibrillation; Catheter ablation; Arrhythmia; Gender

Journal Article.  5308 words.  Illustrated.

Subjects: Cardiovascular Medicine

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