Journal Article

Nucleotide Substitution Bias within the Genus <i>Drosophila</i> Affects the Pattern of Proteome Evolution

Mihai Albu, Xiang Jia Min, G. Brian Golding and Donal Hickey

in Genome Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 1, issue , pages 288-293
Published in print January 2009 |
Published online August 2009 | e-ISSN: 1759-6653 | DOI: https://dx.doi.org/10.1093/gbe/evp028

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The availability of complete genome sequences for 12 Drosophila species provides an unprecedented resource for large-scale studies of genome evolution. In this study, we looked for correlated shifts in the patterns of genome and proteome evolution within the genus Drosophila. Specifically, we asked if the nucleotide composition of the Drosophila willistoni genome—which is significantly less GC rich than the other 11 sequenced Drosophila genomes—is reflected in an altered pattern of amino acid substitutions in the encoded proteins. Our results show that this is indeed the case: There are large and highly significant asymmetries in the patterns of amino acid substitution between D. willistoni and Drosophila melanogaster, and they are in the direction predicted by the nucleotide biases. The implication of this result, combined with previous studies on long-term proteome evolution, is that substitutional biases at the DNA level can be a major factor in determining both the long-term and the short-term directions of proteome evolution.

Keywords: nucleotide content; amino acid composition; GC content

Journal Article.  3905 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology ; Evolutionary Biology ; Genetics and Genomics

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