Journal Article

On Reconciling Single and Recurrent Hitchhiking Models

Jeffrey D. Jensen

in Genome Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 1, issue , pages 320-324
Published in print January 2009 |
Published online September 2009 | e-ISSN: 1759-6653 | DOI: http://dx.doi.org/10.1093/gbe/evp031

More Like This

Show all results sharing these subjects:

  • Bioinformatics and Computational Biology
  • Evolutionary Biology
  • Genetics and Genomics

GO

Show Summary Details

Preview

A major focus of modern population genetics involves using polymorphism data in order to identify regions impacted by recent positive selection (so-called genomic scans). Recently, methodology has been proposed not to identify individual loci, but rather to quantify genomic recurrent hitchhiking (RHH) parameters using this same type of polymorphism data. I here examine to what extent genomic scans for adaptively important loci may be informed by recently estimated RHH parameters (and vice versa). I find that published results are largely incompatible with one another, with approximately an order of magnitude more sweeps being empirically identified than would be predicted under RHH estimates. Results demonstrate that making this connection between SHH and RHH models is crucial for a more complete and accurate characterization of adaptive evolution.

Keywords: genetic hitchhiking; recurrent selection; selective sweeps; genomic scans

Journal Article.  3829 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology ; Evolutionary Biology ; Genetics and Genomics

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.