Journal Article

Viruses with More Than 1,000 Genes: Mamavirus, a New <i>Acanthamoeba polyphaga</i> <i>mimivirus</i> Strain, and Reannotation of Mimivirus Genes

Philippe Colson, Natalya Yutin, Svetlana A. Shabalina, Catherine Robert, Ghislain Fournous, Bernard La Scola, Didier Raoult and Eugene V. Koonin

in Genome Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 3, issue , pages 737-742
Published in print January 2011 |
Published online June 2011 | e-ISSN: 1759-6653 | DOI: http://dx.doi.org/10.1093/gbe/evr048

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The genome sequence of the Mamavirus, a new Acanthamoeba polyphaga mimivirus strain, is reported. With 1,191,693 nt in length and 1,023 predicted protein-coding genes, the Mamavirus has the largest genome among the known viruses. The genomes of the Mamavirus and the previously described Mimivirus are highly similar in both the protein-coding genes and the intergenic regions. However, the Mamavirus contains an extra 5′-terminal segment that encompasses primarily disrupted duplicates of genes present elsewhere in the genome. The Mamavirus also has several unique genes including a small regulatory polyA polymerase subunit that is shared with poxviruses. Detailed analysis of the protein sequences of the two Mimiviruses led to a substantial amendment of the functional annotation of the viral genomes.

Keywords: Mimivirus; viral genome; nucleocytoplasmic large DNA viruses

Journal Article.  2887 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology ; Evolutionary Biology ; Genetics and Genomics

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