Journal Article

Genetic Architecture of Growth Traits Revealed by Global Epistatic Interactions

Lin Xu, Huifeng Jiang, Hong Chen and Zhenglong Gu

in Genome Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 3, issue , pages 909-914
Published in print January 2011 |
Published online August 2011 | e-ISSN: 1759-6653 | DOI: http://dx.doi.org/10.1093/gbe/evr065

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Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Yet, little is known about how it is distributed underlying specific traits. Based on a global map of epistatic interactions in baker's yeast, Saccharomyces cerevisiae, we show that epistasis is prevalent (∼13% increase from random expectation) and displays modular architecture among genes that underlie the same growth traits. More interestingly, our results indicate that hub genes responsible for the same growth traits tend to link epistatically with each other more frequently than random expectation. Our results provide a genome-wide perspective on the genetic architecture of growth traits in a eukaryotic organism.

Keywords: epistasis; hub genes; growth trait

Journal Article.  3148 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology ; Evolutionary Biology ; Genetics and Genomics

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