Journal Article

Use of Senescence-Accelerated Mouse Model in Bleomycin-Induced Lung Injury Suggests That Bone Marrow–Derived Cells Can Alter the Outcome of Lung Injury in Aged Mice

Jianguo Xu, Edilson T. Gonzalez, Smita S. Iyer, Valerie Mac, Ana L. Mora, Roy L. Sutliff, Alana Reed, Kenneth L. Brigham, Patricia Kelly and Mauricio Rojas

in The Journals of Gerontology: Series A

Volume 64A, issue 7, pages 731-739
Published in print July 2009 | ISSN: 1079-5006
Published online April 2009 | e-ISSN: 1758-535X | DOI: http://dx.doi.org/10.1093/gerona/glp040
Use of Senescence-Accelerated Mouse Model in Bleomycin-Induced Lung Injury Suggests That Bone Marrow–Derived Cells Can Alter the Outcome of Lung Injury in Aged Mice

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The incidence of pulmonary fibrosis increases with age. Studies from our group have implicated circulating progenitor cells, termed fibrocytes, in lung fibrosis. In this study, we investigate whether the preceding determinants of inflammation and fibrosis were augmented with aging. We compared responses to intratracheal bleomycin in senescence-accelerated prone mice (SAMP), with responses in age-matched control senescence-accelerated resistant mice (SAMR). SAMP mice demonstrated an exaggerated inflammatory response as evidenced by lung histology. Bleomycin-induced fibrosis was significantly higher in SAMP mice compared with SAMR controls. Consistent with fibrotic changes in the lung, SAMP mice expressed higher levels of transforming growth factor-β1 in the lung. Furthermore, SAMP mice showed higher numbers of fibrocytes and higher levels of stromal cell–derived factor-1 in the peripheral blood. This study provides the novel observation that apart from increases in inflammatory and fibrotic factors in response to injury, the increased mobilization of fibrocytes may be involved in age-related susceptibility to lung fibrosis.

Keywords: Lung; Senescence; Bone marrow; Mice

Journal Article.  4994 words.  Illustrated.

Subjects: Geriatric Medicine ; Public Health ; Biological Sciences ; Molecular and Cell Biology ; Neuroscience

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