Journal Article

A Quantitative Trait Locus on chr.4 Regulates Thymic Involution

Ritu Kumar, Serine Avagyan and Hans-Willem Snoeck

in The Journals of Gerontology: Series A

Volume 65A, issue 6, pages 620-625
Published in print June 2010 | ISSN: 1079-5006
Published online April 2010 | e-ISSN: 1758-535X | DOI: https://dx.doi.org/10.1093/gerona/glq041
A Quantitative Trait Locus on chr.4 Regulates Thymic Involution

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The mechanisms underlying age-associated thymic involution are unknown. In mice, thymic involution shows mouse strain–dependent genetic variation. Identification of the underlying genes would provide mechanistic insight into this elusive process. We previously showed that responsiveness of hematopoietic stem and progenitor cells (HSPCs) to transforming growth factor-beta 2, a positive regulator of HSPC proliferation, is regulated by a quantitative trait locus (QTL) on chr. 4, Tb2r1. Interestingly, Tgfb2+/− mice have delayed thymic involution. Therefore, we tested the hypothesis that a QTL on chr. 4 might regulate thymic involution. Aged, but not young, B6.D2-chr.4 congenic mice, where the telomeric region of chr. 4 was introgressed from DBA/2 to C57BL/6 mice, had larger thymi, and better maintenance of early thymic precursors than C57BL/6 control mice. These observations unequivocally demonstrate that the telomeric region of chr. 4 contains a QTL, Ti1 (thymic involution 1) that regulates thymic involution, and suggest the possibility that Ti1 may be identical to Tb2r1.

Keywords: Quantitative trait locus; Thymic involution

Journal Article.  3829 words.  Illustrated.

Subjects: Geriatric Medicine ; Public Health ; Biological Sciences ; Molecular and Cell Biology ; Neuroscience

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