Journal Article

Expression of histo-blood group antigens by lipopolysaccharides of <i>Helicobacter pylori </i>strains from Asian hosts: the propensity to express type 1 blood-group antigens

Mario A. Monteiro, Peng-yuan Zheng, Bow Ho, Shin-ichi Yokota, Ken-ichi Amano, Zhi-jun Pan, Douglas E. Berg, Kenneth H. Chan, Leann L. MacLean and Malcolm B. Perry

in Glycobiology

Published on behalf of Society for Glycobiology

Volume 10, issue 7, pages 701-713
Published in print July 2000 | ISSN: 0959-6658
Published online July 2000 | e-ISSN: 1460-2423 | DOI: http://dx.doi.org/10.1093/glycob/10.7.701
Expression of histo-blood group antigens by lipopolysaccharides of Helicobacter pylori strains from Asian hosts: the propensity to express type 1 blood-group antigens

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Past studies have shown that the cell surface lipopolysaccharides (LPSs) of the ubiquitous human gastric pathogen Helicobacter pylori (a type 1 carcinogen) isolated from people residing in Europe and North America express predominantly type 2 Lewis x (Lex) and Ley epitopes and, infrequently, type 1 Lea, Leb, and Led antigens. This production of Lewis blood-group structures by H. pylori LPSs, similar to those found in the surfaces of human gastric cells, allows the bacterium to mimic its human niche. In this study, LPSs of H.pylori strains extracted from patients living in China, Japan, and Singapore were chemically and serologically analyzed. When compared with Western H.pylori LPSs, these Asian strains showed a stronger tendency to produce type 1 blood groups. Of particular interest, and novel observations in H.pylori, the O-chain regions of strains F-58C and R-58A carried type 1 Lea without the presence of type 2 Lex, strains R-7A and H607 were shown to have the capability of producing the type 1 blood group A antigen, and strains CA2, H507, and H428 expressed simultaneously the difucosyl isomeric antigens, type 1 Leb and type 2 Ley. The apparent proclivity for the production of type 1 histo-blood group antigens in Asian H.pylori LPSs, as compared with Western strains, may be an adaptive evolutionary effect in that differences in the gastric cell surfaces of the respective hosts might be significantly dissimilar to select for the formation of different LPS structures on the resident H.pylori strain.

Keywords: Key words: Helicobacter pylori/lipopolysaccharides/histo-blood groups/structural determination/molecular mimicry

Journal Article.  8172 words.  Illustrated.

Subjects: Carbohydrates

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