Journal Article

The mouse <i>slalom</i> mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti

Hsun Tsai, Rachel E. Hardisty, Charlotte Rhodes, Amy E. Kiernan, Phil Roby, Zuzanna Tymowska-Lalanne, Philomena Mburu, Sohaila Rastan, A. Jackie Hunter, Steve D. M. Brown and Karen P. Steel

in Human Molecular Genetics

Volume 10, issue 5, pages 507-512
Published in print March 2001 | ISSN: 0964-6906
Published online March 2001 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/10.5.507
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ  of Corti

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The Notch signalling pathway has recently been implicated in the development and patterning of the sensory epithelium in the cochlea, the organ of Corti. As part of an ongoing large-scale mutagenesis programme to identify new deaf or vestibular mouse mutants, we have identified a novel mouse mutant, slalom, which shows abnormalities in the patterning of hair cells in the organ of Corti and missing ampullae, structures that house the sensory epithelia of the semicircular canals. We show that the slalom mutant carries a mutation in the Jagged1 gene, implicating a new ligand in the signalling processes that pattern the inner ear neuro-epithelium.

Journal Article.  3970 words.  Illustrated.

Subjects: Genetics and Genomics

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