Journal Article

Telomerase and cancer

Jerry W. Shay, Ying Zou, Eiso Hiyama and Woodring E. Wright

in Human Molecular Genetics

Volume 10, issue 7, pages 677-685
Published in print April 2001 | ISSN: 0964-6906
Published online April 2001 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/10.7.677
Telomerase and cancer

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Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that associate with telomeres, in order to elucidate mechanisms of telomere length regulation. This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches.

Journal Article.  7328 words.  Illustrated.

Subjects: Genetics and Genomics

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