Journal Article

Anterior segment dysgenesis and the developmental glaucomas are complex traits

Douglas B. Gould and Simon W. M. John

in Human Molecular Genetics

Volume 11, issue 10, pages 1185-1193
Published in print May 2002 | ISSN: 0964-6906
Published online May 2002 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/11.10.1185
Anterior segment dysgenesis and the developmental glaucomas are complex traits

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Glaucoma refers to a heterogeneous group of disorders that involve retinal ganglion cell death, optic nerve damage, and loss of visual field. Glaucoma is a leading cause of vision loss worldwide, affecting an estimated 67 million people. Elevated intraocular pressure is a major risk factor for glaucoma. Individuals with malformations of structures of the anterior segment of the eye frequently develop elevated intraocular pressure and glaucoma. In this review, we focus on the developmental glaucomas, the subset of glaucomas associated with anterior segment dysgenesis. To minimize overlap with other reviews in this issue and elsewhere, we highlight the complex, multifactorial nature of these diseases and recent advances using mice.

Journal Article.  8157 words.  Illustrated.

Subjects: Genetics and Genomics

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