Journal Article

Characterization of the Human <i>Jumonji</i> Gene

Jean-Louis Bergé-Lefranc, Philippe Jay, Annick Massacrier, Pierre Cau, Marie Geneviève Mattei, Sophie Bauer, Catherine Marsollier, Philippe Berta and Michel Fontes

in Human Molecular Genetics

Volume 5, issue 10, pages 1637-1641
Published in print October 1996 | ISSN: 0964-6906
e-ISSN: 1460-2083 | DOI:
Characterization of the Human Jumonji Gene

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While constructing a cDNA library of human embryos, we have isolated a clone homologous to jumonji, a mouse gene required for neural tube formation. We have determined the complete coding sequence of the human homologue (JMJ) and deduced the amino acid sequence of the putative protein. We show here that human and mouse jumonji putative proteins are homologous and present 90% identity. During human embryogenesis, JMJ mRNAs are predominantly expressed in neurons and particularly in dorsal root ganglion cells. They are also expressed in neurons of human adult cerebral cortex. In view of these observations, we propose JMJ as a candidate gene for developmental defects of the central nervous system in the human. The human JMJ gene maps at position 6p24–6p23.

Journal Article.  3220 words.  Illustrated.

Subjects: Genetics and Genomics

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