Journal Article

Genomic Imprinting of Human p57<sup><i>KIP2</i></sup> and Its Reduced Expression in Wilms' Tumors

Izuho Hatada, Johji Inazawa, Tatsuo Abe, Masahiro Nakayama, Yasuhiko Kaneko, Yoshihiro Jinno, Norio Niikawa, Hirofumi Ohashi, Yoshimitsu Fukushima, Kazuki Iida, Chikao Yutani, Shun-ichi Takahashi, Yoshihide Chiba, Sachiko Ohishi and Tsunehiro Mukai

in Human Molecular Genetics

Volume 5, issue 6, pages 783-788
Published in print June 1996 | ISSN: 0964-6906
Published online June 1996 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/5.6.783
Genomic Imprinting of Human p57KIP2 and Its Reduced Expression in Wilms' Tumors

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p57KIP2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57KIP2is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. Genetic analysis of the familial BWS has indicated maternal carriers and suggested a role in genomic imprinting. Previously, we demonstrated that p57KIP2is imprinted in the mouse. Here we describe the genomic imprinting of human p57KIP2and the reduction of its expression in Wilms' tumors. High resolution mapping locates p57KIP2 in the region responsible for both tumor suppressivity and BWS.

Journal Article.  3994 words.  Illustrated.

Subjects: Genetics and Genomics

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