Journal Article

A Gene for Autosomal Dominant Late-Onset Progressive Non-Syndromic Hearing Loss, <i>DFNA10</i>, Maps to Chromosome 6

Marsha E. O'Neill, Jacquie Marietta, Darryl Nishimura, Sigrid Wayne, Guy Van Camp, Lut Van Laer, Clelia Negrini, Edward R. Wilcox, Achih Chen, Kunihiro Fukushima, Li Ni, Val C. Sheffield and Richard J. H. Smith

in Human Molecular Genetics

Volume 5, issue 6, pages 853-856
Published in print June 1996 | ISSN: 0964-6906
Published online June 1996 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/5.6.853
A Gene for Autosomal Dominant Late-Onset Progressive Non-Syndromic Hearing Loss, DFNA10, Maps to Chromosome 6

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Late-onset non-syndromic hearing impairment is the most common type of neurological dysfunction in the elderly. It can be either acquired or inherited, although the relative impact of heredity on this type of loss is not known. To date, nine different genes have been localized, but none has been cloned. Using an extended American family in which a gene for autosomal dominant late-onset non-syndromic hearing impairment is segregating, we have identified a new locus, DFNA10, on chromosome 6.

Journal Article.  2300 words.  Illustrated.

Subjects: Genetics and Genomics

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