Journal Article

Frequent Deletion of Chromosome 1p Sequences in an Aggressive Histologic Subtype of Endometrial Cancer

Martin F. Arlt, Thomas J. Herzog, David G. Mutch, Deborah J. Gersell, Hua Liu and Paul J. Goodfellow

in Human Molecular Genetics

Volume 5, issue 7, pages 1017-1021
Published in print July 1996 | ISSN: 0964-6906
Published online July 1996 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/5.7.1017
Frequent Deletion of Chromosome 1p Sequences in an Aggressive Histologic Subtype of Endometrial Cancer

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The molecular genetic events underlying endometrial tumorigenesis are ill-defined at present. We have identified a region on the short arm of chromosome 1 which is frequently deleted in endometrial cancers. The region of deletion has been localized to bands 1p32–33. Deletion of 1p32–33 is seen more frequently in cancers of the highly aggressive papillary serous type than in cancers of the less-aggressive endometrioid type. These data suggest the presence of a tumor suppressor gene on 1p32–33 which is specifically involved in the development of endometrial cancers with poor outcome.

Journal Article.  3263 words.  Illustrated.

Subjects: Genetics and Genomics

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