Journal Article

Saturation Multipoint Linkage Mapping of Chromosome 6q in Type 1 Diabetes

June L. Davies, Francesco Cucca, Juliet V. Goy, Zeinat A. A. Atta, Marilyn E. Merriman, Amanda Wilson, Anthony H. Barnett, Stephen C. Bain and John A. Todd

in Human Molecular Genetics

Volume 5, issue 7, pages 1071-1074
Published in print July 1996 | ISSN: 0964-6906
Published online July 1996 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/5.7.1071
Saturation Multipoint Linkage Mapping of Chromosome 6q in Type 1 Diabetes

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Linkage analysis of type 1 diabetes sib pair families (n = 334) has suggested two separate regions of human chromosome 6q are linked to disease (designated IDDM5 and IDDM8). To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92% informative map of chromosome 6q and multipoint analysis. The two regions still showed positive evidence of linkage, most notably the proterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006; λs = 1.17). In addition, some evidence of transmission disequilibrium was seen with marker a046xa9 (IDDM5).

Journal Article.  3056 words.  Illustrated.

Subjects: Genetics and Genomics

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