Journal Article

Association between Atopic Asthma and a Coding Variant of FcεRIβ in a Japanese Population

T. Shirakawa, X.-Q. Mao, S. Sasaki, T. Enomoto, M. Kawai, K. Morimoto and J. Hopkin

in Human Molecular Genetics

Volume 5, issue 8, pages 1129-1130
Published in print August 1996 | ISSN: 0964-6906
Published online August 1996 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/5.8.1129
Association between Atopic Asthma and a Coding Variant of FcεRIβ in a Japanese Population

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A genetic association study was performed with coding variants of FcεRIβ in relation to atopic and non-atopic asthma in a Japanese population (n=400). A coding variant of Gly237Glu in exon 7 of FcεRIβ gene showed association with atopic asthma (OR = 3.00, χ2 = 5.10, p <0.03), but not with non-atopic asthma; this was seen particularly in childhood asthma (OR = 3.92, χ2 = 8.66, p <0.005). This variant is also associated with very high total serum IgE levels (>mean + 3 SD, OR = 8.56, χ2 = 46.2, p <0.0001), but not any allergen specific IgE. However, Leu181Ile, another variant of FcεRIβ related to atopy in British and Australian populations, was not found in this Japanese population. These results suggest that variants of FcεRIβ may be an important genetic cause of the atopic asthma.

Journal Article.  1182 words.  Illustrated.

Subjects: Genetics and Genomics

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