Journal Article

Genetic Modification of the Phenotypes Produced by Amyloid Precursor Protein Overexpression in Transgenic Mice

George A. Carlson, David R. Borchelt, Angela Dake, Sherry Turner, Valerie Danielson, J. Douglas Coffin, Chris Eckman, James Meiners, Steven P. Nilsen, Steven G. Younkin and Karen K. Hsiao

in Human Molecular Genetics

Volume 6, issue 11, pages 1951-1959
Published in print October 1997 | ISSN: 0964-6906
Published online October 1997 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/6.11.1951
Genetic Modification of the Phenotypes Produced by Amyloid Precursor Protein Overexpression in Transgenic Mice

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Overexpression of Alzheimer amyloid precursor protein (APP) produces dramatically different phenotypes in transgenic mice depending on the genetic background. For example, concentrations of APP that produce amyloid plaques in outbred transgenic lines are lethal for inbred FVB/N or C57BL/6J mice. Expression of SOD1 transgenes is protective, suggesting involvement of oxidative damage in premature death, but ablation of Apoe had no significant effect. In contrast, FGF2 transgene overexpression enhances the lethal effects of APP. Differential survival does not appear to reflect genetic differences in APP processing, but rather host responses to APP or its derivatives.

Journal Article.  7415 words.  Illustrated.

Subjects: Genetics and Genomics

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