Journal Article

Linkage mapping of benign familial infantile convulsions (BFIC) to chromosome 19q

Michel Guipponi, François Rivier, Federico Vigevano, Corinne Beck, Arielle Crespel, Bernard Echenne, Pierpaolo Lucchini, Rosella Sebastianelli, Michel Baldy-Moulinier and Alain Malafosse

in Human Molecular Genetics

Volume 6, issue 3, pages 473-477
Published in print March 1997 | ISSN: 0964-6906
Published online March 1997 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/6.3.473
Linkage mapping of benign familial infantile convulsions (BFIC) to chromosome 19q

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Benign familial infantile convulsions (BFIC) are an autosomal-dominant epileptic syndrome characterized by an age of onset within the first year of life. Although they were first reported in families of Italian descent, BFIC have also been described in non-Italian families. We have mapped the BFIC gene to chromosome 19 by linkage analysis in five Italian families with a maximum two-point lod score of 6.36 at D19S114; maximum multipoint lod scores >8 were obtained for the interval D19S250–D19S245. BFIC are therefore the third idiopathic partial epileptic syndrome to be mapped on the human genome.

Journal Article.  1887 words.  Illustrated.

Subjects: Genetics and Genomics

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