Journal Article

The Human <i>Achaete-Scute</i> Homologue 2 (ASCL2, HASH2) Maps to Chromosome 11p15.5, Close to IGF2 and is Expressed in Extravillus Trophoblasts

Mariëlle Alders, Matthew Hodges, Anna-Katerina Hadjantonakis, Jan Postmus, Inge van Wijk, Jet Bliek, Maurice de Meulemeester, Andries Westerveld, François Guillemot, Cees Oudejans, Peter Little and Marcel Mannens

in Human Molecular Genetics

Volume 6, issue 6, pages 859-867
Published in print June 1997 | ISSN: 0964-6906
Published online June 1997 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/6.6.859
The Human Achaete-Scute Homologue 2 (ASCL2, HASH2) Maps to Chromosome 11p15.5, Close to IGF2 and is Expressed in Extravillus Trophoblasts

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Here we describe the cloning of the human Achaete Scute Homologue 2 (HASH2) gene, officially designated ASCL2 (Achaete Scute complex like 2), a homologue of the DrosophilaAchaete and Scute genes. In mouse, this gene is imprinted and maps to chromosome 7. We mapped the human homologue close to IGF2 and H19 at 11p15.5, the human region syntenic with mouse chromosome 7, indicating that this imprinted region is highly conserved in mouse and man. HASH2 is expressed in the extravillus trophoblasts of the developing placenta only. The lack of HASH2 expression in non-malignant hydatidiform (androgenetic) moles indicates that HASH2 is also imprinted in man.

Journal Article.  4380 words.  Illustrated.

Subjects: Genetics and Genomics

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