Journal Article

The Human <i>FXY</i> Gene is Located Within Xp22.3: Implications for Evolution of the Mammalian X Chromosome

Jo Perry, Sally Feather, Alice Smith, Steve Palmer and Alan Ashworth

in Human Molecular Genetics

Volume 7, issue 2, pages 299-305
Published in print February 1998 | ISSN: 0964-6906
Published online February 1998 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/7.2.299
The Human FXY Gene is Located Within Xp22.3: Implications for Evolution of the Mammalian X Chromosome

Show Summary Details

Preview

It has been proposed that the pseudoautosomal region of mammals has evolved by sequential addition of autosomal material onto the X and Y chromosomes followed by movement of the pseudoautosomal boundary to create X-unique regions. We have previously described a gene, Fxy, that spans the pseudoautosomal boundary in mice such that the first three exons of the gene are located on the X chromosome, but the remainder of the gene is located on both X and Y chromosomes. Therefore, this gene might be in a state of transition between pseudoautosomal and X-unique locations. In support of this theory we show here that the human FXY gene is located in Xp22.3 in humans, proximal to the pseudoautosomal boundary.

Journal Article.  5041 words.  Illustrated.

Subjects: Genetics and Genomics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.