Journal Article

<i>IMPT1</i>, an Imprinted Gene Similar to Polyspecific Transporter and Multi-Drug Resistance Genes

Diem Dao, Dale Frank, Naifeng Qian, Denise O'Keefe, Robert J. Vosatka, Colum P. Walsh and Benjamin Tycko

in Human Molecular Genetics

Volume 7, issue 4, pages 597-608
Published in print April 1998 | ISSN: 0964-6906
Published online April 1998 | e-ISSN: 1460-2083 | DOI:
IMPT1, an Imprinted Gene Similar to Polyspecific Transporter and Multi-Drug Resistance Genes

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Human chromosome 11p15.5 and distal mouse chromosome 7 include a megabase-scale chromosomal domain with multiple genes subject to parental imprinting. Here we describe mouse and human versions of a novel imprinted gene, IMPT1, which lies between IPL and p57KIP2 and which encodes a predicted multi-membrane-spanning protein similar to bacterial and eukaryotic polyspecific metabolite transporter and multi-drug resistance pumps. Mouse Imptl and human IMPT1 mRNAs are highly expressed in tissues with metabolite transport functions, including liver, kidney, intestine, extra-embryonic membranes and placenta, and there is strongly preferential expression of the maternal allele in various mouse tissues at fetal stages. In post-natal tissues there is persistent expression, but the allelic bias attenuates. An allelic expression bias is also observed in human fetal and postnatal tissues, but there is significant interindividual variation and rare somatic allele switching. The fact that Imptl is relatively repressed on the paternal allele, together with data from other imprinted genes, allows a statistical conclusion that the primary effect of human chromosome 11p15.5/mouse distal chromosome 7 imprinting is domain-wide relative repression of genes on the paternal homolog. Dosage regulation of the metabolite transporter gene(s) by imprinting might regulate placental and fetal growth.

Journal Article.  7543 words.  Illustrated.

Subjects: Genetics and Genomics

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