Journal Article

A Chromosome 4P Haplotype Segregating with Parkinson's Disease and Postural Tremor

Matt Farrer, Katrina Gwinn-Hardy, Manfred Muenter, Fabienne Wavrant DeVrieze, Richard Crook, Jordi Perez-Tur, Sarah Lincoln, Demetrius Maraganore, Charles Adler, Stephanie Newman, Kari MacElwee, Page McCarthy, Carol Miller, Cheryl Waters and John Hardy

in Human Molecular Genetics

Volume 8, issue 1, pages 81-85
Published in print January 1999 | ISSN: 0964-6906
Published online January 1999 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/8.1.81
A Chromosome 4P Haplotype Segregating with Parkinson's Disease and Postural Tremor

Show Summary Details

Preview

We investigated a large family with levodopa-responsive, Lewy body parkinsonism in which the disease segregates as an apparent autosomal dominant trait. After performing a genome screen, we identified a chromosome 4p haplotype that segregates with the disease. However, this haplotype also occurs in individuals in the pedigree who do not have clinical Lewy body parkinsonism but rather suffer from postural tremor, consistent with essential tremor. These data demonstrate a new locus for Lewy body parkinsonism and suggest that in some circumstances postural tremor can be an alternative phenotype of the same pathogenic mutation as Lewy body parkinsonism.

Journal Article.  4122 words.  Illustrated.

Subjects: Genetics and Genomics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.