Journal Article

A Genome-Wide Screen for Asthma-Associated Quantitative Trait Loci in a Mouse Model of Allergic Asthma

Youming Zhang, Jean Lefort, Virginia Kearsey, José Roberto Lapa e Silva, William O. C. M. Cookson and B. Boris Vargaftig

in Human Molecular Genetics

Volume 8, issue 4, pages 601-605
Published in print April 1999 | ISSN: 0964-6906
Published online April 1999 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/8.4.601
A Genome-Wide Screen for Asthma-Associated Quantitative Trait Loci in a Mouse Model of Allergic Asthma

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Asthma is the most common illness of childhood, affecting one child in seven in the UK. Asthma has a genetic basis, but genetic studies of asthma in humans are confounded by uncontrolled environmental factors, varying penetrance and phenotypic pleiotropy. An animal model of asthma would offer controlled exposure, limited and consistent genetic variation, and unlimited size of sibships. Following immunization and subsequent challenge with ovalbumin, the Biozzi BP2 mouse shows features of asthma, including airway inflammation, eosinophil infiltration and non-specific bronchial responsiveness. In order to identify genetic loci influencing these traits, a cross was made between BP2 and BALB/c mice, and a genome-wide screen carried out in the F2 progeny of the F1 intercross. Five potentially linked loci were identified, four of which corresponded to human regions of syntenic homology that previously have shown linkage to asthma-associated traits.

Journal Article.  3373 words.  Illustrated.

Subjects: Genetics and Genomics

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