Journal Article

Linkage and Association of Atopic Asthma to Markers on Chromosome 13 in the Japanese Population

Kazumi Kimura, Emiko Noguchi, Masanao Shibasaki, Tadao Arinami, Yukako Yokouchi, Kazunori Takeda, Kimiko Yamakawa-Kobayashi, Akira Matsui and Hideo Hamaguchi

in Human Molecular Genetics

Volume 8, issue 8, pages 1487-1490
Published in print August 1999 | ISSN: 0964-6906
Published online August 1999 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/8.8.1487
Linkage and Association of Atopic Asthma to Markers on Chromosome 13 in the Japanese Population

Show Summary Details

Preview

Chromosome 13 contains several candidate genes for asthma and atopy, and markers on this chromosome have been shown to be linked to phenotypes of atopy or asthma in two genome-wide searches. We conducted a linkage study for atopic asthma using markers spanning the whole of chromosome 13 in Japanese families ascertained through asthmatic children and examined associations of atopic asthma with markers where linkage was suggested. Data were analysed using MAPMAKER/SIBS for the multipoint lod score (MLS) analysis and SIB-PAIR for the transmission disequilibrium test (TDT). Three peaks which exceeded a lod score of 1.0 were observed (MLS 2.4 between D13S175 and D13S217, MLS 2.0 between D13S153 and D13S156, and MLS 1.4 between D13S285 and D13S293). The global TDT for atopic asthma was significant for the marker D13S153 (P = 0.0065) and the 96 bp allele of D13S153 was preferentially transmitted to atopic asthma-affected children (P = 0.0009, Bonferroni correction 5% = 0.0037, 1% = 0.00072). These findings indicate that genes on chromosome 13 may play an important role in the development of atopy or asthma across various populations.

Journal Article.  3260 words.  Illustrated.

Subjects: Genetics and Genomics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.