Journal Article

Counting cross-overs: characterizing meiotic recombination in mammals

Terry Hassold, Stephanie Sherman and Patricia Hunt

in Human Molecular Genetics

Volume 9, issue 16, pages 2409-2419
Published in print October 2000 | ISSN: 0964-6906
Published online October 2000 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/9.16.2409
Counting cross-overs: characterizing meiotic recombination in mammals

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Until recently, most of our understanding of meiotic recombination has come from studies of lower eukaryotes. However, over the past few years several components of the mammalian meiotic recombination pathway have been identified, and new molecular and cytological approaches to the analysis of mammalian meiosis have been developed. In this review, we discuss recent advances in three areas: the application of new techniques to study genome-wide levels of recombination in individual meioses; studies analyzing temporal aspects of the mammalian recombination pathway; and studies linking the genesis of human trisomies to alterations in meiotic exchange patterns.

Journal Article.  9005 words.  Illustrated.

Subjects: Genetics and Genomics

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