Journal Article

Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q

Derek W. Morris, Lucie Robinson, Darko Turic, Mary Duke, Victoria Webb, Charis Milham, Elizabeth Hopkin, Kirsty Pound, Shamira Fernando, Martha Easton, Marian Hamshere, Nigel Williams, Peter McGuffin, Jim Stevenson, Michael Krawczak, Michael J. Owen, Michael C. O’Donovan and Julie Williams

in Human Molecular Genetics

Volume 9, issue 5, pages 843-848
Published in print March 2000 | ISSN: 0964-6906
Published online March 2000 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/9.5.843
Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q

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Family-based association mapping was used to follow up reports of linkage between reading disability (RD) and a genomic region on chromosome 15q. Using a two-stage approach, we ascertained 101 (stage 1) and 77 (stage 2) parent–proband trios, in which RD was characterized rigorously. In stage 1, a set of eight microsatellite markers spanning the region of putative linkage was used and a highly significant association was detected between RD and a three-marker haplotype (D15S994/D15S214/D15S146: P and empirical P < 0.001). A significant association with the same three-marker haplotype was also observed in the second-stage sample (P = 0.009, empirical P = 0.006). Our data therefore provide strong evidence for one or more genes contributing to RD being located in the vicinity of the region including D15S146 and D15S994. In addition, our results provide support for association analysis being a useful method to map susceptibility loci for complex disorders.

Journal Article.  4864 words.  Illustrated.

Subjects: Genetics and Genomics

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