Journal Article

A role for <i>Caenorhabditis elegans</i> in understanding the function and interactions of human disease genes

Emmanuel Culetto and David B. Sattelle

in Human Molecular Genetics

Volume 9, issue 6, pages 869-877
Published in print April 2000 | ISSN: 0964-6906
Published online April 2000 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/9.6.869
A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes

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A growing number of medical research teams have begun to explore the experimental advantages of using a genetic animal model, the nematode worm Caenorhabditis elegans, with a view to enhancing our understanding of genes underlying human congenital disorders. In this study, we have compared sequences of positionally cloned human disease genes with the C.elegans database of predicted genes. Drawing on examples from spinal muscular atrophy, polycystic kidney disease, muscular dystrophy and Alzheimer’s disease, we illustrate how data from C.elegans can yield new insights into the function and interactions of human disease genes.

Journal Article.  6807 words.  Illustrated.

Subjects: Genetics and Genomics

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