Journal Article

Zebrafish developmental genetics and central nervous system development

P. Blader and U. Strähle

in Human Molecular Genetics

Volume 9, issue 6, pages 945-951
Published in print April 2000 | ISSN: 0964-6906
Published online April 2000 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/9.6.945
Zebrafish developmental genetics and central nervous system development

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The central nervous system (CNS) is the most complex tissue of vertebrates. Recently, the zebrafish has emerged as a powerful genetic system for studying early development, and large-scale mutagenic screens for embryonic patterning defects have been accomplished. Mutants isolated in these screens are proving helpful in unravelling the mole­cular hierarchies involved in the development of the CNS. We review here recent studies in zebrafish which shed light on the genetic pathways involved in induction and regionalization of the CNS.

Journal Article.  6307 words.  Illustrated.

Subjects: Genetics and Genomics

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