Journal Article

Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease

Ruth Luthi-Carter, Andrew Strand, Nikki L. Peters, Steven M. Solano, Zane R. Hollingsworth, Anil S. Menon, Ariel S. Frey, Boris S. Spektor, Ellen B. Penney, Gabriele Schilling, Christopher A. Ross, David R. Borchelt, Stephen J. Tapscott, Anne B. Young, Jang-Ho J. Cha and James M. Olson

in Human Molecular Genetics

Volume 9, issue 9, pages 1259-1271
Published in print May 2000 | ISSN: 0964-6906
Published online May 2000 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/9.9.1259
Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease

Show Summary Details

Preview

To understand gene expression changes mediated by a polyglutamine repeat expansion in the human huntingtin protein, we used oligonucleotide DNA arrays to profile ~6000 striatal mRNAs in the R6/2 mouse, a transgenic Huntington’s disease (HD) model. We found diminished levels of mRNAs encoding components of the neurotransmitter, calcium and retinoid signaling pathways at both early and late symptomatic time points (6 and 12 weeks of age). We observed similar changes in gene expression in another HD mouse model (N171-82Q). These results demonstrate that mutant huntingtin directly or indirectly reduces the expression of a distinct set of genes involved in signaling pathways known to be critical to striatal neuron function.

Journal Article.  8451 words.  Illustrated.

Subjects: Genetics and Genomics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.