Journal Article

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

Jianchao Xu, Pandelakis A. Koni, Peili Wang, Guoyong Li, Leonard Kaczmarek, Yanling Wu, Yanyan Li, Richard A. Flavell and Gary V. Desir

in Human Molecular Genetics

Volume 12, issue 5, pages 551-559
Published in print March 2003 | ISSN: 0964-6906
Published online March 2003 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddg049
The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

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Voltage-gated potassium (Kv) channels regulate cell membrane potential and control a variety of cellular processes. Kv1.3 channels are expressed in several tissues and believed to participate in cell volume regulation, apoptosis, T cell activation and renal solute homeostasis. Examination of Kv1.3-deficient mice (Kv1.3−/−), generated by gene targeting, revealed a previously unrecognized role for Kv1.3 in body weight regulation. Indeed, Kv1.3−/− mice weigh significantly less than control littermates. Moreover, knockout mice are protected from diet-induced obesity and gain significantly less weight than littermate controls when placed on a high-fat diet. While food intake did not differ significantly between Kv1.3−/− and controls, basal metabolic rate, measured at rest by indirect calorimetry, was significantly higher in knockout animals. These data indicate that Kv1.3 channels may participate in the pathways that regulate body weight and that channel inhibition increases basal metabolic rate.

Journal Article.  3598 words.  Illustrated.

Subjects: Genetics and Genomics

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