Journal Article

Normal and abnormal dental development

Isabelle Miletich and Paul T. Sharpe

in Human Molecular Genetics

Volume 12, issue suppl_1, pages R69-R73
Published in print April 2003 | ISSN: 0964-6906
Published online April 2003 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddg085
Normal and abnormal dental development

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Teeth are vertebrate organs that arise from complex and progressive interactions between an ectoderm, the oral epithelium and an underlying mesenchyme. During their early development, tooth germs exhibit many morphological and molecular similarities with other developing epithelial appendages, such as hair follicles, mammary and salivary glands, lungs, kidneys, etc. The developing mouse tooth germ, which is an experimentally accessible model for organogenesis, provides a powerful tool for elucidating the molecular mechanisms that control the development of these organs. Dentition patterning also provides a unique model for understanding how different shapes of teeth arise in different regions of the jaws. We review here the main signalling networks mediating the epithelial–mesenchymal interactions involved in tooth morphogenesis and patterning.

Journal Article.  4363 words.  Illustrated.

Subjects: Genetics and Genomics

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