Journal Article

Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma

Hyoung Doo Shin, Byung Lae Park, Lyoung Hyo Kim, Ji Hyun Jung, Jun Yeon Kim, Jung Hwan Yoon, Yoon Jun Kim and Hyo-Suk Lee

in Human Molecular Genetics

Volume 12, issue 8, pages 901-906
Published in print April 2003 | ISSN: 0964-6906
Published online April 2003 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddg104
Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma

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Interleukin 10 (IL10) is a powerful Th-2 cell cytokine produced by lymphoid cells that exerts its functions by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFA, TGFB, IL6, IL8 and IL12). Genetic association analysis of a well-characterized HBV cohort revealed that one of IL10 haplotypes, IL10-ht2, was strongly associated with hepatocellular carcinoma (HCC) occurrence in gene dose-dependent manner. The frequency of susceptible IL10-ht2 was much higher in HCC patients and significantly increased in order of susceptibility to HBV progression from chronic hepatitis to liver cirrhosis and HCC among hepatitis B patients. In addition, survival analysis clearly showed that the onset age of HCC was also accelerated among chronic hepatitis B patients who were carrying IL10-ht2. Increased IL10 production mediated by IL10-ht2 suggests that up-regulated IL10 accelerates progression of chronic HBV infection, especially to HCC development.

Journal Article.  3411 words.  Illustrated.

Subjects: Genetics and Genomics

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