Journal Article

Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p

Maolian Gong, Hongye Zhang, Herbert Schulz, Young-Ae Lee, Kai Sun, Sylvia Bähring, Friedrich C. Luft, Peter Nürnberg, André Reis, Klaus Rohde, Detlev Ganten, Rutai Hui and Norbert Hübner

in Human Molecular Genetics

Volume 12, issue 11, pages 1273-1277
Published in print June 2003 | ISSN: 0964-6906
Published online June 2003 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddg135
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p

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Essential (primary) hypertension is an important risk factor for cardiovascular morbidity and mortality. Blood pressure is largely heritable; however, the genetic factors contributing to essential hypertension are mostly unknown. We examined a large Chinese kindred (n=387) and selected a subset of 94 individuals for genotyping. An additional 32 Chinese nuclear families with essential hypertension were also recruited. Genome-wide parametric linkage analysis identified a new locus for primary hypertension on chromosome 12p (parametric LOD score 3.44). This locus overlaps with the assigned locus that causes severe autosomal-dominant hypertension and brachydactyly, the only form of monogenic hypertension known to date that resembles primary hypertension. We suggest that this genomic region, spanning 18 annotated genes, will be of great relevance in elucidating new mechanisms for primary hypertension.

Journal Article.  2888 words.  Illustrated.

Subjects: Genetics and Genomics

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