Journal Article

The Newfoundland population: a unique resource for genetic investigation of complex diseases†

Proton Rahman, Albert Jones, Joseph Curtis, Sylvia Bartlett, Lynette Peddle, Bridget A. Fernandez and Nelson B. Freimer

in Human Molecular Genetics

Volume 12, issue suppl_2, pages R167-R172
Published in print October 2003 | ISSN: 0964-6906
Published online October 2003 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddg257
The Newfoundland population: a unique resource for genetic investigation of complex diseases†

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The population of the province of Newfoundland and Labrador is genetically isolated. This isolation is evidenced by an overabundance of several monogenic disorders. The Newfoundland population, like that of other isolates, is now the focus of interest for identification of genes implicated in common diseases. However, the utility of such populations for this purpose remains unproven. In this paper, we review the current genetic architecture of the province, with respect to geographic isolation, homogeneity, founder effect, genetic drift and extended linkage disequilibrium. Based on these factors, we propose that the population of Newfoundland offers many advantages for genetic mapping of common diseases, compared with admixed populations, and even compared with other isolates.

Journal Article.  4268 words.  Illustrated.

Subjects: Genetics and Genomics

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