Journal Article

Genomic microarrays in human genetic disease and cancer

Donna G. Albertson and Daniel Pinkel

in Human Molecular Genetics

Volume 12, issue suppl_2, pages R145-R152
Published in print October 2003 | ISSN: 0964-6906
Published online October 2003 | e-ISSN: 1460-2083 | DOI:
Genomic microarrays in human genetic disease and cancer

Show Summary Details


Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of solid tumors and are found in association with developmental abnormalities and/or mental retardation. Comparative genomic hybridization (CGH) can be used to detect and map these changes. Recent improvements in the resolution and sensitivity of CGH have been possible through implementation of microarray-based CGH (array CGH). Here we discuss the performance characteristics of different array platforms and review some of the recent applications of array CGH in cancer and medical genetics.

Journal Article.  6484 words.  Illustrated.

Subjects: Genetics and Genomics

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