Journal Article

The potential role of gene duplications in the evolution of imprinting mechanisms

Jörn Walter and Martina Paulsen

in Human Molecular Genetics

Volume 12, issue suppl_2, pages R215-R220
Published in print October 2003 | ISSN: 0964-6906
Published online October 2003 | e-ISSN: 1460-2083 | DOI: http://dx.doi.org/10.1093/hmg/ddg296
The potential role of gene duplications in the evolution of imprinting mechanisms

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Using the completed genomic sequences of mouse and human we performed a comparative analyses of imprinted genes and gene clusters. For many imprinted genes we could detect imprinted as well as non-imprinted paralogues. The inter- and intrachromosomal similarities between paralogues and their linkage to imprinting clusters suggests that imprinted genes were dispersed throughout the genome by gene duplications as well as translocation and transposition events. Our findings indicate that imprinting clusters may have been linked together on one (or a few) ancestral pre-imprinted chromosome(s), arguing for a common mechanistic origin of imprinting control. Imprinting may originally have evolved on a simple basis of dosage compensation required for some duplicated genes (chromosomes) followed by selection of sex-biased expression control.

Journal Article.  4002 words.  Illustrated.

Subjects: Genetics and Genomics

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